Adult stem cell therapy for heart disease

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When the body is injured, stem cells travel the scene of the accident. Some come from the bone marrow, a modest number of others, from the heart itself. There, they may help heal damaged tissue.

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Cardiovascular disease is the number one cause of death worldwide in men and women worldwide, claiming more than 17 million lives each year. Heart attacks cause damage to the heart muscle, making it less efficient at pumping blood throughout the circulatory system. The heart has minimal ability to regenerate, so the lost muscle is replaced by scar tissue.

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The journal, published sinceis the official publication of the Spanish Society of Cardiology and founder of the REC Publications journal family. Articles are published in both English an Spanish in its electronic edition. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years.

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Stem cells and derived products offer great promise for new medical treatments. Learn about stem cell types, current and possible uses, ethical issues, and the state of research and practice. You've heard about stem cells in the news, and perhaps you've wondered if they might help you or a loved one with a serious disease.

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Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and heart diseaseamong others.

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Cardiovascular diseases CVD still represent the leading cause of mortality worldwide, despite the remarkable advances in interventional cardiology, cardiac surgery, and modern pharmacotherapy, particularly in the setting of acute myocardial infarction AMIchronic ischemic heart failure HFcardiomyopathy CMand the associated left ventricular LV dysfunction. A significant loss of cardiomyocytes that underlies all of these conditions was previously considered irreversible. However, current evidence indicates that the human heart has some potential for repair, and over the past decade, many research studies have been exploring the use of stem cells SCs to facilitate restoration of myocardium.

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CNN Following heart attacks, a handful of monkeys regained some of the pumping ability their hearts had lost after being given human embryonic stem cells, according to a study published Monday in Nature Biotechnology. CNN's Susan Scutti contributed to this report. Correction: This story has been updated to correct the spelling of Dr.

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The heart works tirelessly for a whole lifetime, pumping fresh blood to the far reaches of the body, supplying oxygen and nutrients. When the heart itself is deprived of blood caused by a blocked artery, the affected tissue withers and scars and can no longer beat see figure below. According to the World Health Organization, ischemic heart disease is the number one cause of death in men and women worldwide, far surpassing cancers and infectious diseases. Figure: When an artery is blocked by a plaque buildup or blood clot the heart is deprived of oxygen, leading to the death of heart muscle.

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We performed a large-scale meta-analysis of randomized clinical trials to investigate the efficacy and safety of SCT in IHF patients. Fourteen eligible randomized controlled trials were included in this study, for a total of IHF patients, of which patients were treated with SCT. In addition, SCT does not affect mortality.

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In a world first, scientists have found a new way to direct stem cells to heart tissue. The findings, led by researchers at the University of Bristol and published in Chemical Sciencecould radically improve the treatment for cardiovascular disease, which causes more than a quarter of all deaths in the UK. To date, trials using stem cells, which are taken and grown from the patient or donor and injected into the patient's heart to regenerate damaged tissue, have produced promising results. However, while these next generation cell therapies are on the horizon, significant challenges associated with the distribution of the stem cells have remained.

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